We often work on problems where there are no off-the-shelf statistical methods. Thus, an important part of our work is in developing appropriate statistical and computational approaches that can yield new insights into biological data.
3/31/2014. Congratulations to former lab member Melissa Hubisz, now at Cornell, for winning an NSF predoc award! Also well done to Jessica, Emily and Evan for honorable mentions.
12/18/2014. Alexis, Zia and Sidney's paper on the relationship between genetic variation and phenotypic variation in RNA, ribosomes, and proteins is out today. Congrats!
12/16/2014. Congratulations to Cristina who completed her Ph.D defense in CS yesterday!!
12/04/2014. Anil and Heejung's paper on using multi-scale approaches to model DNase data at TF binding sites is out on bioRxiv.
9/22/2014. Lots of new arrivals this month: David, Yang, Anand and Emily; visiting scholars: Audrey, Towfique and Kyle. Welcome!
8/07/2014. This week we are moving into our long-term lab space in the Clark Center! We are very happy to be in the new space. In other news, Anand has been awarded a CEHG fellowship for next year. Well done, Anand!
6/24/2014. Alexis will be starting her own lab next month at Johns Hopkins in the departments of CS and Biostats [Link]. We wish her all the very best in her new position!!
6/24/2014. Well done to Eilon on winning the prestigious EMBO fellowship! David Golan, who will be joining in September has been awarded the Rothschild and Fulbright fellowships. Congrats to both!!
6/24/2014. Xun and Nick's paper on genetic influences on DNA methylation is out on bioRxiv [Link].
4/29/2014. Anil's fastSTRUCTURE paper is now out in Genetics: Link.
Alexis will be speaking next week at Biology of Genomes about her work with Zia and Sydney on understanding the effects of genetic variation on mRNA, translation and proteins.
4/2/2014. Darren Cusanovich's paper on knockdown of TFs in LCLs (with Yoav's lab) is out now in PLOS Genetics: Link. Choongwon Jeong's paper on adaptive introgression of high altitude adaptations from Sherpa into Tibetans (collaboration with Anna Di Rienzo's lab), is out now in Nature Communications: Link.
4/1/2014. Bon voyage to Heejung Kim; she spent the winter term visiting us from Matthew's lab in Chicago.
3/1/2014. Welcome to Yair who has now arrived from Chicago with his family!
2/10/2014. Our paper on genetic load in human populations, joint with Guy Sella's lab, is out now in Nature Genetics. Well done to Yuval Simons (in Guy's lab) and Michael Turchin (now in Matthew Stephens' lab)! Link.
2/10/2014. Welcome to our new postdoc Eilon Sharon, who has moved here from Eran Segal's lab. Eilon will be joint with Hunter Fraser's lab. Welcome also to this term's rotation students: Peyton Greenside, Natalie Telis, Diego Calderon, Arbel Harpak and Emily Glassberg!
12/6/2013. Joe Davis has written a great blog post about Graham and Bryce's recent paper on genetic variation and histone modification.
12/4/2013. fastSTRUCTURE is out! Links to Anil's manuscript and beta-release software are here.
12/4/2013. Thanks to Christine Vogel for her perspective on Zia's evolution of mRNA/protein paper.
11/12/2013. Welcome to Yonggan and Priya who are joining the lab this month!
11/1/2013. There's a nice perspective in NRG by Hannah Storey on 4 recent papers--including one by Graham and Bryce--that studied the effects of genetic variation on histone mods.
10/30/2013. Kudos to Shyam for winning the prestigious Charles Epstein Trainee Research Award (postdoc division) for his talk at ASHG on historical inference for African populations. Graham Coop is a previous winner from our lab (in 2007).
10/22/2013. Congratulations to lab alum Joe Pickrell who has just accepted a position as one of the first faculty at the New York Genome Center. In addition, Zia Khan is now in transit to his first faculty position--in CS at U. Maryland. Good luck to both!
10/22/2013. Darren's paper on knockdown experiments targeting 59 TFs is out on ArXiv.
10/17/2013. Zia and Graham/Bryce have a pair of papers out in Science today: evolution of protein expression in primates and effects of genetic variation on histone modifications. Congrats to Zia, Graham and Bryce!
10/11/2013. Welcome to our first two Stanford rotation students: Ilana Arbisser from the Biology department and Michael Sikora from Genetics!
8/1/2013. We are delighted to be moving to Stanford University. This will be a fantastic academic environment and a great place to live. That said, we will miss our many friends at the University of Chicago, where the lab was based for 12 years.
8/1/2013. Welcome to our newest postdoc Alexis Battle! It's great to have her onboard.
8/1/2013. Welcome to Anil, Stoyan and Xun, who are arriving at Stanford this month. The rest of the lab will follow soon or work from Chicago during the transitional period.
5/10/2013. Our paper with Guy Sella's lab "The deleterious mutation load is insensitive to recent population history" is out on arXiv. We show that the mutation load is very similar in European and African Americans, and argue that rare mutations are only likely to be important for traits that have direct fitness consequences.